The famous leader known for the quote, "Give me liberty, or give me death!" is Patrick Henry. He delivered this stirring phrase during a speech in the Virginia Convention in 1775, advocating for armed resistance against British oppression. His passionate articulation of the desire for freedom has made this statement one of the most celebrated in American history. Henry's leadership and rhetoric played a significant role in galvanizing public sentiment in support of the American Revolution, emphasizing themes of liberty and self-determination.