The genre of gothic literature was significantly impacted by major influences such as Romanticism and the exploration of the human psyche following the Industrial Revolution. Mary Shelley’s seminal work, "Frankenstein," blends elements of horror, nature, and the consequences of scientific exploration, emphasizing the tension between human emotion and rationality. Additionally, themes of isolation, societal critique, and the supernatural played crucial roles in shaping gothic literature, contributing to its continued evolution and relevance.