Marie Curie confronted several obstacles in her scientific career, including gender bias and limited access to resources. As a female scientist in the early 20th century, she faced skepticism and discrimination within the scientific community. Despite these barriers, Curie's groundbreaking research on radioactivity led to her becoming the first woman to earn a Nobel Prize. She also struggled with financial difficulties while conducting her experiments, often resorting to makeshift laboratories. Curie's determination and innovative spirit allowed her to overcome societal norms and establish herself as a pioneering figure in science, paving the way for future generations of women in academia.