John Keats faced several obstacles throughout his career that deeply influenced his poetry. He experienced profound personal loss, including the deaths of his brother and parents, which brought themes of grief and mortality to his work. Additionally, financial struggles and the pressures of gaining recognition as a poet posed constant challenges. Keats battled tuberculosis, which ultimately led to his early death, adding an element of urgency and poignancy to his writings. Despite these hardships, his dedication to beauty and profound emotional expression made him one of the most beloved Romantic poets. His works reflect a complex interplay of joy and sorrow, illustrating the human experience.