Hippocrates introduced significant changes in the field of medicine by establishing a systematic approach to clinical practice. His emphasis on observation and documentation laid the groundwork for a more empirical understanding of disease and treatment. He is credited with the Hippocratic Oath, which set ethical standards for physicians and guided their practice. Hippocrates’ focus on the natural causes of illness, rather than supernatural explanations, shifted the paradigms of medical thought. His legacy endures in modern medicine, shaping the principles of patient care and clinical methodology that are still relevant today.