Mark Twain’s writings hold significant importance in American literature due to their exploration of essential themes like race, identity, and the complexities of human nature. His most famous works, such as "The Adventures of Tom Sawyer" and "The Adventures of Huckleberry Finn," utilize a combination of humor, satire, and realistic portrayal of American society during the 19th century. Twain’s sharp insights on social issues and his distinctive narrative voice not only entertain but challenge readers to reflect on ethical and moral questions. His impact resonates through literary studies, shape the American voice, and influence countless writers.