The prominent film director born in 1945 in the United States is Martin Scorsese. Known for his exceptional storytelling and visual style, Scorsese has directed critically acclaimed films such as "Taxi Driver", "Goodfellas", and "The Irishman". His work often explores themes of identity, crime, and culture. Scorsese's contributions to the film industry have earned him numerous awards, including an Academy Award for Best Director. He is regarded as one of the greatest filmmakers of all time.