Best practices for writing answers in the UPSC Mains Examination include clarity and conciseness while addressing the question. Candidates should focus on structuring their answers logically, starting with an introduction, followed by the main content, and a conclusion. Using bullet points, headings, and subheadings can enhance readability. Additionally, integrating relevant examples and facts reinforces arguments and demonstrates depth of knowledge. Time management is crucial; candidates should allocate time wisely for each question and practice writing under timed conditions to improve speed and coherence.