To tackle negative marking in the UPSC Preliminary exam, candidates should focus on practicing with mock tests to become familiar with the exam pattern and time management. Ensuring that they understand the negative marking system helps with risk assessment during decision-making on each question. It is crucial to read questions carefully to avoid unnecessary mistakes. Being thorough in conceptual clarity allows aspirants to confidently answer questions without second-guessing. Additionally, working on elimination techniques can help avoid wild guesses that lead to penalties.