Strategies to enhance the clarity and coherence of responses in the UPSC Mains exam include structured thinking and organizing answers with a clear introduction, body, and conclusion. Using bullet points for key ideas within the response can enhance readability. Practicing answer writing is crucial, as it helps aspirants articulate their thoughts clearly within the time constraints of the exam. Familiarity with the syllabus and marking schemes will guide the depth of answers. Lastly, reviewing and self-analysing previous responses can help in identifying strengths and areas for improvement, promoting continuous enhancement.