The body of water that separates Italy from the Balkans is known as the Adriatic Sea. This sea stretches along the eastern side of Italy and runs down the western coast of the Balkan Peninsula. It serves as an important shipping route and has been historically significant for trade and cultural exchange between the two regions. The Adriatic is also popular for its clear waters, picturesque coastlines, and numerous islands, making it a favored destination for tourists and sailors.