Changes in metabolism can significantly affect weight loss efforts. A slower metabolism results in fewer calories burned at rest, making it more challenging to lose weight. Factors such as age, muscle mass, and physical activity levels play a crucial role in metabolic rates. Additionally, metabolic adaptations may occur with significant weight loss, leading to decreased energy requirements. To combat these effects, individuals can incorporate resistance training to build muscle mass, engage in regular physical activity to boost overall caloric expenditure, and ensure they consume sufficient nutrients to support a healthy metabolism.