Hormones significantly influence metabolism and weight loss by regulating various physiological processes. Key hormones like insulin, leptin, and ghrelin control hunger, energy expenditure, and fat storage. For instance, insulin helps manage blood sugar and fat storage, while leptin signals satiety. An imbalance in these hormones can lead to weight gain or difficulty losing weight. Additionally, stress hormones like cortisol may promote fat retention, particularly in the abdomen. Managing these hormonal responses through diet, exercise, and sleep is crucial for optimizing metabolism and achieving weight loss goals.