The body reacts to long-term stress through the activation of the stress response, releasing hormones such as cortisol and adrenaline. While this response is helpful in short bursts, chronic activation can lead to various negative health outcomes. Prolonged stress can impair immune function, disrupt sleep patterns, increase the risk of cardiovascular diseases, and contribute to mental health issues like anxiety and depression. It's important to manage stress through strategies like exercise, mindfulness, and proper nutrition to mitigate its harmful effects and promote overall well-being.