The significance of antioxidants in combating oxidative stress lies in their ability to neutralize free radicals. Oxidative stress can lead to various chronic diseases, including cancer, heart disease, and neurodegenerative disorders. Antioxidants, such as vitamins C and E, and compounds found in fruits and vegetables, work to protect cells from damage. By reducing oxidative stress, antioxidants help maintain cellular health and potentially enhance overall well-being. Therefore, a diet rich in antioxidants is essential for promoting long-term health.