A fitness program for weight loss should focus on creating a calorie deficit while incorporating both aerobic and strength training exercises. Cardiovascular activities, such as running or cycling, help burn calories, while strength training builds lean muscle, which increases metabolic rate. It's also crucial to emphasize nutrition, ensuring a balanced intake of macronutrients and portion control. Consistency and gradual progress are key, along with setting realistic goals and monitoring progress for motivation and adherence to the program.