The organ primarily responsible for detoxification in the body is the liver. The liver processes nutrients absorbed from the digestive tract and transforms toxic substances into less harmful components. It plays a vital role in metabolizing drugs and alcohol, breaking down waste products, and filtering blood. The liver also produces bile, which aids in the digestion of fats. A healthy liver is crucial for overall wellness, as it helps maintain homeostasis and supports various bodily functions, making its detoxification abilities essential for maintaining health.