The major event that took place at the Alamo in 1836 was a pivotal battle during the Texas Revolution. A group of Texan defenders, including notable figures like James Bowie and Davy Crockett, held out against a much larger Mexican army led by General Antonio López de Santa Anna. The siege lasted from February 23 to March 6, culminating in the Mexican forces overwhelming the Alamo and killing most of its defenders. This event became a symbol of resistance and heroism for Texan independence, inspiring further uprisings and ultimately leading to the Republic of Texas's establishment later that year.