The significance of the signing of the Treaty of Paris in 1763 was that it marked the end of the Seven Years' War, a global conflict that involved most of the great powers of the time. The treaty predominantly benefitted Great Britain, granting it control over Canada, Florida, and significant territories east of the Mississippi River. France ceded Louisiana to Spain and lost its influence in North America. The treaty redrew colonial boundaries, ultimately altering the balance of power in North America and setting the stage for future tensions between Britain and its American colonies, contributing to the American Revolutionary War.