The influential queen of ancient Egypt known for her alliance with Rome was Cleopatra VII. She reigned from 51 to 30 BCE and is famous for her relationships with prominent Roman leaders Julius Caesar and Mark Antony. Cleopatra's diplomatic skills and charisma allowed her to forge strategic alliances that aimed to protect her kingdom from Roman expansion. Her reign marked the end of the Ptolemaic Kingdom of Egypt as a significant political entity. Despite her efforts, her defeat in the Battle of Actium in 31 BCE led to the annexation of Egypt by Rome and the end of Hellenistic rule in the region.