In Mesopotamian mythology, the ancient being known for making the first sacrifice to the gods is Gilgamesh. He represents the quest for immortality and the acknowledgement of human mortality. His sacrifice to the gods symbolizes a pivotal moment in mythological narratives, where the divine and mortal worlds interact. This act reflects the essential themes of devotion, the complexity of human-divine relationships, and the realization that sacrifices are integral to achieving a deeper connection with the divine.