The mythological creature known for its ability to regenerate lost limbs is the Hydra. In Greek mythology, the Hydra is a multi-headed serpent; when one head is cut off, two more grow in its place. It represents the challenges of facing seemingly insurmountable obstacles, as its regeneration symbolizes the struggle against evil or chaos. Hercules faced the Hydra as one of his Twelve Labors, illustrating the themes of persistence and overcoming adversity.