The Greek hero known for slaying **Medusa** is Perseus. Equipped with divine gifts such as a reflective shield and winged sandals, Perseus undertakes the perilous quest to defeat Medusa, a Gorgon whose gaze could turn anyone to stone. With courage and cunning, he successfully beheads her, later using her head as a weapon. His victory over Medusa cements his legacy as one of the great heroes of Greek mythology, highlighting themes of bravery and adventure.