The primary detoxifying agent in the human liver is glutathione. This tripeptide plays a crucial role in the detoxification process, helping to neutralize harmful substances like free radicals, heavy metals, and toxins. Glutathione works by conjugating with these substances, making them more water-soluble and easier for the body to excrete through urine or bile. Maintaining adequate levels of glutathione is essential for proper liver function and overall health, as it also supports the immune system and acts as an important antioxidant.