The significance of using animal models in biomedical research lies in their ability to mimic human physiology and disease, providing valuable insights into biological processes. Animal models, such as mice and rats, facilitate the study of complex interactions between genes, environment, and health, allowing researchers to investigate disease mechanisms and potential treatments. These models play a crucial role in preclinical testing, helping to assess the safety and efficacy of new therapies before human trials. Ultimately, animal research contributes to advancements in medical science and improved patient care.