The organ primarily responsible for regulating body temperature is the hypothalamus, located in the brain. The hypothalamus acts as the body’s thermostat, detecting changes in internal temperature and initiating appropriate physiological responses to maintain homeostasis. It regulates processes such as sweating, shivering, and altering blood flow to the skin. Additionally, factors like hormonal signals and environmental conditions can also influence temperature regulation. This ability to maintain a stable internal environment is critical for overall health and proper functioning of biological systems.