The highest score a single player can achieve in one game of ten-pin bowling is 300, which is referred to as a "perfect game." Achieving this score requires the bowler to roll twelve consecutive strikes, one in each of the first ten frames and two additional strikes in the bonus frame. This level of performance demonstrates exceptional skill, consistency, and control. A perfect game is the ultimate goal for bowlers, showcasing their ability to maintain focus and precision throughout the entire game.