The highest score ever recorded in a single NBA game by one player is 100 points, achieved by Wilt Chamberlain on March 2, 1962. This remarkable feat occurred during a game between the Philadelphia Warriors and the New York Knicks in Hershey, Pennsylvania. Chamberlain's scoring spree included a combination of field goals and free throws, showcasing his dominance on the court. This record stands unchallenged and remains one of the most iconic moments in sports history.