The main advantage of using high-level programming languages is that they provide increased abstraction from the hardware, making the coding process more intuitive. These languages, such as Python or Java, often use human-readable syntax, allowing developers to write code more quickly and with fewer errors. They offer built-in functions and libraries, accelerating development time and enhancing productivity. Additionally, high-level languages typically come with robust community support and extensive documentation, making it easier for developers to troubleshoot problems and learn.