The main advantage of using RESTful APIs is their simplicity and ease of integration across different systems and platforms. They utilize standard HTTP methods like GET, POST, PUT, and DELETE to facilitate communication between clients and servers, making them highly accessible. JSON is commonly used for data interchange, ensuring lightweight and easy-to-read responses. RESTful APIs are stateless, which enhances scalability, as each request contains all necessary information to process it. Moreover, their adherence to Web standards promotes interoperability, enabling a broader range of applications to connect and work together, essential for modern software development.