The significance of cloud-native design principles lies in their ability to optimize applications for the cloud environment, fostering scalability, resilience, and flexibility. By embracing microservices architecture and containerization, teams can deploy and manage applications independently, enhancing speed and ease of development. Cloud-native solutions are designed to automatically scale in response to user demand, making them more efficient and cost-effective. Additionally, they enable continuous delivery and integration, allowing frequent updates and faster innovation. Overall, these principles empower organizations to leverage the full potential of cloud computing for modern application development.