The significance of device interoperability in home automation lies in the ability of various devices and systems to work together seamlessly. Interoperability ensures that different brands and types of devices can communicate and function as a unified system, enhancing user experience and convenience. This integration allows users to control lighting, security, and appliances from a single interface or mobile app, maximizing automation benefits. Additionally, interoperability fosters innovation, as it encourages manufacturers to create products that can easily integrate into existing ecosystems, ultimately driving consumer preferences and advancing the smart home market.