HTTP/2 is significant in web protocols as it enhances the performance and efficiency of web communications. By utilizing features such as multiplexing, which allows multiple requests and responses to be sent simultaneously over a single connection, it greatly reduces loading times. Additionally, HTTP/2 employs header compression to minimize the amount of redundant data transmitted. This modern protocol also supports server push, enabling servers to send resources to clients before they explicitly request them, further enhancing user experience. Overall, HTTP/2 plays a crucial role in optimizing web interactions.