The significance of user permissions in software applications lies in the management of access controls and security. By defining who can access particular resources and functionalities, organizations can protect sensitive data from unauthorized users. Proper user permissions enhance data integrity and support compliance with regulations by ensuring that only authorized personnel can perform specific actions. This framework is essential in preventing data breaches and maintaining user privacy. Additionally, it fosters accountability within the system, as actions can be traced back to specific users, ensuring responsible usage of the application.